Endocrine Abstracts

A normal thyroid status is crucial for normal tissue and organ functioning, including temperature homeostasis. The tissue-specific actions of TH on body temperature regulation and thermogenesis are largely modulated via thyroid hormone receptor TRα. Consequently, mice expressing a mutant TRα display bradycardia and a reduced body temperature at 22°C ambient temperature due to excessive heat loss via the tail. To test whether this peripheral heat loss is the sole...

A normal thyroid status is crucial for correct tissue and organ function, including temperature homeostasis. The tissue-specific actions of thyroid hormone on body temperature regulation in humans and rodents are largely modulated via the nuclear thyroid hormone receptor TRα1. Consequently, mice expressing a mutant TRα1R384C display a reduced core body temperature at 22°C caused by excessive heat loss via the tail. Surprisingly, the hypothermic phenotype of TR&#...

Background and Aim: Thyroid hormone beta receptor (TRβ) agonists have shown promising results to improve non-alcoholic steatohepatitis in preclinical studies and clinical trials. However, a recent cross-sectional study on human liver biopsies found that TRβ expression decreases during non-alcoholic steatohepatitis (NASH), which may indicate developing thyroid hormone resistance and pose a challenge for TRβ agonists. We aim to study how the changes in TRβ ex...

Objectives: Thyroid hormones (TH) affect cardiovascular functions via direct actions on the heart and via indirect actions on central nervous system. Mutations in TH receptor α1 (TRα1) cause Resistance to Thyroid Hormone α (RTHα), a disorder characterized by hypothyroidism in TRα1-expressing tissues including the heart.Methods: The current experiments aimed at investigating the role of peripheral and central TR&...